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Vladanka Topalovuć

Research Assistant

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:   +381 65 3976 212               
Phone:   +381 11 3976 212
Fax:       +381 11 397 58 08
E-mail: vladankatopalovic@imgge.bg.ac.rs

EDUCATION

2011 - PhD student, FB, UB

2011 - M.Sc. in Molecular Biology and Physiology, FB, UB

RESEARCH EXPERIENCE

2014 - Research Assistant, IMGGE, UB

2012 - 2014 - Research TraineeIMGGE, UB

CAREER HISTORY

2012 - Laboratory for human molecular genetics, IMGGE, UB

2013 - 2014 - Erasmus Mundus SIGMA Sholar, University of Milan, Italy

2010 - EPFL Summer Research Program Scholar, École polytechnique fédérale de Lausanne, Lausanne, Switzerland

RESEARCH INTEREST

  • Analysis of the epigenetic mechanisms involved in the regulation of human SOXB1 genes expression during process of neural differentiation
  • Studying the interplay between Wnt/β-catenin signaling pathway and SOXB1 genes in NT2/D1 cells
  • Analysis of themolecular diversity of Serbian population based on mitochondrial DNA polymorphisms

SELECTED PUBLICATIONS

1. Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling. Mojsin M, Vicentic JM, Schwirtlich M,Topalovic V, Stevanovic M, Food Funct. 2014 Oct 24;5(10):2564-73

http://www.ncbi.nlm.nih.gov/pubmed/25138740

2. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I,Topalovic V, Stevanovic M, BMB Rep. 2014 Apr;47(4):197-202.

http://www.ncbi.nlm.nih.gov/pubmed/24257117

3. The influence of combined oral contraceptives containing drospirenone on hypothalamic-pituitary-adrenocortical axis activity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome. Macut Dj, Bozic Antic I, Nestorov J, Topalovic V, Panidis D, Kastratovic Kotlica B, Papadakis E, Matic G, Vojnovic Milutinovic D, Hormones, (DOI.10.14310/horm.2002.1526)

http://www.hormones.gr/8530/article/the-influence-of-combined-oral-contraceptives%E2%80%A6.html

4. Quercetin and lithium chloride modulate Wnt signaling in pluripotent embryonal carcinoma NT2/D1 cells. Mojsin M, Topalovic V, Marjanovic J, Stevanovoc M. Archives of Biological Sciences, 2013; 65(1)201-209

http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641301201M#.VE9nmDTF-2Y

Marija Švirtlih

Research Associate
Laboratory for human molecular genetics

Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mob:    +381 65 3976212
Tel:      +381 11 3976212
Fax:     +381 11 397 58 08
E-mail: schwirtlich@imgge.bg.ac.rs

EDUCATION

2009 - PhD in Medical Sciences, Semmelweiss University, Budapest, Hungary. In 2012, nostrificated as PhD in Biological Sciences, Faculty of Biology (FB), UB (Molecular components and functionality of the GABA signaling during development: a study on two model systems)

1998 - B.Sc. in Molecular Biology and Physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2012 - Research Associate,
Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

CAREER HISTORY

2012 - esearch Associate,Laboratory for human molecular genetics
Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

2001 - 2010 - Research Fellow, Laboratory of Molecular Biology and Genetics, Institute of

                           Experimental Medicine

                           Hungarian Academy of Sciences,

                           Budapest, Hungary

1998 - 2001 - Research Trainee, Department of Neurobiology, Institute for Biological        Research “Sinisa Stankovic”, Belgrade, Serbia 

RESEARCH INTEREST

Study on expression and function of SOXB1(SOX1, SOX2, SOX3) and SOXB2 (SOX14 and SOX21) members of SOXB transcription factors during proliferation of embryonic and cancer stem cells. Furthermore, SOXB transcription factors involvement in the regulation of numerous developmental processes in the brain.

SELECTED PUBLICATIONS

In press:

  1. Drakulic D, Marjanovic Vicentic J, Schwirtlich M, Tosic J, Krstic A, Klajn
    A, Stevanovic M. The overexpression of SOX2 affects the migration of human
    teratocarcinoma cell line NT2/D1. An. Acad. Bras. Ciênc., 2014
  2. Klajn A, Drakulic D, Tosic M, Pavkovic Z, Schwirtlich M, Stevanovic M.
    Effects of constitutive SOX2 overexpression on neural differentiation of
    NT2/D1 cells. Biochemistry (Moscow), 2014

Published:

  1. Mojsin M, Vicentic JM, Schwirtlich M, Topalovic V, Stevanovic M. Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling. Food Funct. 2014 Oct 24;5(10):2564-73.  http://www.ncbi.nlm.nih.gov/pubmed/25138740
  2. Vastagh C, Schwirtlich M, Kwakowsky A, Erdélyi F, Margolis FL, Yanagawa Y, Katarova Z, Szabó G. The spatio-temporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons. Dev Neurobiol. 2014 Aug 14. http://www.ncbi.nlm.nih.gov/pubmed/25125027
  3. Popovic J, Stanisavljevic D, Schwirtlich M, Klajn A, Marjanovic J, Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. PLoS One. 2014 Mar 17;9(3):e91852. http://www.ncbi.nlm.nih.gov/pubmed/24637840
  4. Schwirtlich M, Kwakowsky A, Emri Z, Antal K, Lacza Z, Cselenyák A, Katarova Z, Szabó G. GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation. Cell Calcium. 2011 Oct;50(4):381-92. http://www.ncbi.nlm.nih.gov/pubmed/21820173
  5. Schwirtlich M, Emri Z, Antal K, Máté Z, Katarova Z, Szabó G. GABA(A) and GABA(B) receptors of distinct properties affect oppositely the proliferation of mouse embryonic stem cells through synergistic elevation of intracellular Ca(2+). FASEB J. 2010 Apr;24(4):1218-28. http://www.ncbi.nlm.nih.gov/pubmed/19959723
  6. Kwakowsky A, Schwirtlich M, Kooy F, Abrahám I, Máté Z, Katarova Z, Szabó G. GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality. Dev Dyn. 2008 Dec;237(12):3830-41. http://www.ncbi.nlm.nih.gov/pubmed/18985723
    1. Kwakowsky A, Schwirtlich M, Zhang Q, Eisenstat DD, Erdélyi F, Baranyi M, Katarova ZD, Szabó G. GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5. Dev Dyn. 2007 Dec;236(12):3532-44.  http://www.ncbi.nlm.nih.gov/pubmed/17969168

Milena Stevanović

Academician, Principal Research Fellow

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:   +381 64  8044085                           
Phone:   +381 11 397 62 12
Fax:       +381 11 397 58 08
E-mail: milenastevanovic@imgge.bg.ac.rs

EDUCATION

1990 - PhD in Biological Sciences, Faculty of Biology (FB), UB (THESIS: Structural analysis of three haplotypes of β globin gene family encoding globine chains of hemoglobin in rats Rattus Norvegicus)

1987 - M.Sc. in Biological Sciences, FB, UB

1983 - B.Sc. in Molecular Biology, FB, University of Belgrade

RESEARCH EXPERIENCE

2000 - Principal Research Fellow Laboratory for Human Molecular Genetics (LHMG), IMGGE, UB

1996 - 2000 - Senior Research Associate LHMG, IMGGE, UB

1991 - 1996 - Research Associate LHMG, IMGGE, UB

1988 - 1991 - Research Assistant Genome Structure Unit (GSU), IMGGE

1986 - 1988 - Research Trainee GSU, IMGGE

CAREER HISTORY

2015 - Full member of Serbian Academy of Sciences and Arts

2009 - Member of Serbian Academy of Sciences and Arts

2007 - Lecturer on FB, UB, PhD studies in Molecular biology

2007 - Member of the Scientific board for Biology, Ministry of Education, Science and Technological Development, Republic of Serbia

2005 - 2014 - Member of the Steering Committee of the Serbian Biological Society

2004 - 2006 - Member of The University Council, UB

2003 - Member of the National Committee for Bioethics of UNESCO Commission of the Republic of Serbia

2001 - 2007 - Member of Committee for Biology, Ministry of Science and Technological Development, Republic of Serbia

2001 - 2006 - President of the Scientific Council, IMGGE

1999 - Lecturer on FB, UB, Bachelor Studies, course Basic gene manipulation

1999 - 2001 - Acting president of the Board, IMGGE

1994 - Head of Laboratory for Human Molecular Genetics (LHMG), IMGGE, UB

1993 - 2010 - Member of the Board, IMGGE

1992 - 1994 - Post-doc, Genetics Department, University of Cambridge, UK

1991 - 1992 - Post-doc, Imperial Cancer Research Fund, London, UK

1986 -1991 - Genome Structure Unit, IMGGE

RESEARCH INTEREST

Studying the structure and regulation of human SOX genes expression: identification of control elements involved in transcriptional regulation and analysis of the roles of Wnt and Sonic Hedgehog (SHH) signalling pathways in control of their expression; Studying the involvement of epigenetic mechanisms in the control of SOX genes expression; Investigation of the roles of SOX genes in maintaining pluripotency, cell fate determination and differentiation; Studying the roles of SOX genes in oncogenesis. High-resolution phylogenetic studies of mitochondrial DNA variation in contemporary Serbian population, as well as in ancient populations that lived in the Southwestern region of Serbia from Bronze Age up to Middle Ages; Detection of micro-deletion syndromes by Fluorescent in situ Hybridization (FISH).

SELECTED PUBLICATIONS

  1. Mojsin M., Topalovic V., Vicentic J.M., Schwirtlich M., Stanisavljevic D., Drakulic D., Stevanovic M. Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 2015. 144:429-41. http://www.ncbi.nlm.nih.gov/pubmed/26239426
  1. Davidovic S., Malyarchuk B., Aleksic J.M., Derenko M., Topalovic V., Litvinov A., Stevanovic M., Kovacevic-Grujicic N. Mitochondrial DNA perspective of Serbian genetic diversity. Am J Phys Anthropol 2015. 156:449-465. http://www.ncbi.nlm.nih.gov/pubmed/25418795
  1. Petrovic, Milivojevic M., Popovic J., Schwirtlich M., Rankovic B., Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines.PLoS One. 2015. 10(11):e0143591. http://www.ncbi.nlm.nih.gov/pubmed/26588701
  1. Popovic J., Stanisavljevic D., Schwirtlich M., Klajn A., Marjanovic J., Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. 2014. PLoS One, 9:e91852. http://www.ncbi.nlm.nih.gov/pubmed/24637840
  1. Mojsin M., Vicentic J.M., Schwirtlich M., Topalovic V., Stevanovic M. Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling. 2014. Food Funct, 5:2564-73. http://www.ncbi.nlm.nih.gov/pubmed/25138740
  1. Popović V., Živković J., Davidović S., Stevanović M., Stojković D. Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action. 2013. Curr Top Med Chem,13:2791-806. http://www.ncbi.nlm.nih.gov/pubmed/24083788
  1. Drakulic D., Krstic A.,Stevanovic M. Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones. 2012. Genet Mol Res,11:1385-400. http://www.ncbi.nlm.nih.gov/pubmed/22653585
  1. CuturiloG., Menten B., Krstic A., Drakulic D., Jovanovic I., Parezanovic V., Stevanovic M. 4q34.1-q35.2 deletion in a boy with phenotype resembling 22q11.2 deletion syndrome. 2011. Eur J Pediatr, 170:1465-70. http://www.ncbi.nlm.nih.gov/pubmed/21833498
  1. Popovic J., Klajn A., Petrovic I., Stevanovic M.Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. 2010. Biochim Biophys Acta: Gene Regulatory Mechanisms, 1799: 411–418. http://www.ncbi.nlm.nih.gov/pubmed/20074681
  1. Petrovic I., Kovacevic-Grujicic N., Stevanovic M. Early growth response protein 1 acts as an activator of SOX18 promoter. 2010. Exp Mol Med., 42:132-42. http://www.ncbi.nlm.nih.gov/pubmed/20054233
  1. Mojsin M., Stevanovic M. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. 2010. Biochem J, 425:107-16. http://www.ncbi.nlm.nih.gov/pubmed/19799567
  1. Nikčević G., Savić T., Kovačević-Grujičić N., Stevanović M. Up-regulation of the SOX3gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. 2008. J Neurochem, 107: 1206-15. http://www.ncbi.nlm.nih.gov/pubmed/18786169
  1. Kovačević-Grujičić N., Mojsin M., Krstić A., Stevanović M. Functional characterization of the human SOX3 promoter: Identification of transcription factors implicated in basal promoter activity. 2005. Gene, 344: 287-97. http://www.ncbi.nlm.nih.gov/pubmed/15656994
  1. Stevanovic M. Modulation of SOX2 and SOX3 gene expression during differentiation of human neuronal precursor cell line NTERA2. 2003. Mol Biol Rep, 30: 127-132. http://www.ncbi.nlm.nih.gov/pubmed/12841584
  1. Colignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M., Norris D., Ratan S., Stevanović M., Goodfellow P. N., Lovell-Badge R. A comparison of the properties of           Sox-3 with Sry and two related genes, Sox-1 and Sox-2. 1996. Development, 122: 509-520. http://www.ncbi.nlm.nih.gov/pubmed/8625802
  1. Stevanović M., Zuffardi O., Collignone J., Lovell-Badge R., and Goodfellow P. The cDNA sequence and chromosomal location of the human SOX2 gene. 1994. Mamm Genome, 5: 640-642. http://www.ncbi.nlm.nih.gov/pubmed/7849401
  1. Foster J.W., Dominguez-Steglich M.A., Guioli S., Kwok C., Weller P.A., Stevanović M., Weissenbach J., Mansour S., Young I.D., Goodfellow P.N., Brook J.D., Schafer A.J. Campomelic dysplasia and autosomal sex reversal caused by mutation in an Sry-related gene. 1994. Nature, 372: 525-530. http://www.ncbi.nlm.nih.gov/pubmed/7990924
  1. Stevanović M., Lovell-Badge R., Collignone J., Goodfellow, P. SOX3 is an X-linked        gene related to SRY. 1993. Hum Mol Genet, 2: 2013-2018. http://www.ncbi.nlm.nih.gov/pubmed/8111369
  1. Farr C.J., Stevanović M., Thomson E.J., Goodfellow P., Cooke, H.J. Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis. 1992. Nat Genet, 2: 275-282. http://www.ncbi.nlm.nih.gov/pubmed/1303279
  1. Stevanović M., Paunesku T., Radosavljević D., Drmanac R., Crkvenjakov R. Variant chromosomal arrangement of adult β-globin genes in rat. 1989. Gene, 79: 139-150. http://www.ncbi.nlm.nih.gov/pubmed/2777087

Danijela Stanisavljević

Research Associate
Laboratory for Human Molecular Genetics

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:    +381 65  3976212                           
Phone:    +381 11 397 62 12
Fax:        +381 11 397 58 08
E-mail: danijelastanisavljevic@imgge.bg.ac.rs

EDUCATION

2011 - PhD student, Faculty of Biology, University of Belgrade

2004-2011 - M.Sc. in Biology, Faculty of Biology, University of Belgrade

RESEARCH EXPERIENCE

2013 - Research Associate, Laboratory for Human Molecular Genetics, IMGGE

2011 - 2013 - Research Trainee, Laboratory for Human Molecular Genetics, IMGGE

CAREER HISTORY

2011 - Laboratory for Human Molecular Genetics, IMGGE

RESEARCH INTEREST

  • Expression analysis of SOXB genes during in vitro neural differentiation of embryonal carcinoma cells.
  • Analysis of molecular mechanisms that involved human SOX genes during processes of in vitro neurogenesis and
  • Characterisation of human SOX14 gene function.
  • Introducing and application of flluorescent in situ hybridization (FISH) for detection of numerical and structural chromosome aberations in human.

SELECTED PUBLICATIONS

  1. Popovic J.,Stanisavljevic D.,Schwirtlich M.,Klajn A.,Marjanovic J.,Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. 2014. PloS One.Mar 17;9(3)

http://www.ncbi.nlm.nih.gov/pubmed/24637840

  1. Spasojevic N., Jovanovic P., Stanisavljevic D., Stefanovic B., Dronjak S. Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. 2013. Neurochemical Journal, 7 (2), 139-143.

http://link.springer.com.proxy.kobson.nb.rs:2048/article/10.1134/S1819712413020050

  1. Spasojevic N., Stanisavljevic D., Gavrilovic L., Jovanovic P., Cucakovic A., Dronjak S.  Hippocampal asymmetry in expression of catecholamine synthesizing enzyme and transporters in socially isolated rats. 2012. Neuroendocrinology Letters, 33, 631-635.

http://www.ncbi.nlm.nih.gov/pubmed/23160224